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May 6, 2019 - Preempting Drug Resistance in Malaria

Maciej Boni, PhD

Associate Professor of Biology, Pennsylvania State University

Monday, May 6, 2019
12:00 – 1:00 PM
1149 Public Health


Dr. Boni will speak on "Preempting Drug Resistance in Malaria". Drug resistance has emerged to all antimalarial drugs. With resistance to the artemisinin-class drugs confirmed in 2008, there are now no available options for last-line-of-defense drugs should these new resistant genotypes spread worldwide. He will present some classic problems in drug-resistance management; demonstrate that some drug distribution methods may act to slow down resistance evolution; verify these results with individual-based microsimulations of malaria epidemics and drug-resistance evolution; and propose some changes to global malaria management strategy in different zones of malaria endemicity.

About the speaker:

Maciej BoniDr. Boni's academic background is in mathematical epidemiology, mathematical population genetics, individual-based disease transmission models, field epidemiology, phylogenetics, and recombination. His main areas of research are the evolution of antimalarial drug resistance and the dynamics and evolution of influenza virus. His malaria work has focused on optimal methods of distributing antimalarial drugs to minimize future risks of drug resistance, evaluating risks of drug-resistance emergence during mass drug administration, and planning for the introduction of novel antimalarial compounds. From 2008 to 2016, his research group was based in Ho Chi Minh City at the Oxford University Clinical Research Unit. In 2016, he joined the Biology Department and the Center for Infectious Disease Dynamics (CIDD) at Pennsylvania State University.



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